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Mitochondrial ORF of the twelve S rRNA type-c
MOTS-C 10 mg
A sixteen-amino-acid peptide encoded by the mitochondrial genome rather than the nuclear one. Its discovery changed the idea that mitochondria only produce energy: they also send signals to the rest of the cell. Circulating levels fall with age and with insulin resistance.
- CAS
- 1627580-64-6
- Formula
- C101H152N28O22S2
- Molecular weight
- 2174.6 g/mol
- Sequence
- Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
- Purity
- ≥ 98% verified by HPLC
- Presentation
- Amber glass vial with lyophilized powder, vacuum sealed.
- Includes 3 ml BAC waterIn the same box, at no cost.
How it works
- Activates the AMPK pathway, the cell's central energy-state sensor.
- Takes part in folate metabolism and in the homocysteine pathway.
- Translocates to the nucleus under metabolic stress and regulates antioxidant response genes.
- Increases glucose uptake in skeletal muscle in experimental models.
Qué dice la evidencia
- Identification of the mitochondria-derived peptide and its effect on metabolic homeostasis via AMPK.
- Association between circulating levels and insulin sensitivity in a human population.
Route described in the studies
- Route
- Subcutaneous. Protocols describe application while fasting or before exercise.
- Preparation
- Reconstitute with BAC WATER against the vial wall, without shaking.
- Application site
- Alternate the site with each application.
Documented effects
- Transient local discomfort
- Limited human safety data
When it is not used
- Recurrent uncontrolled hypoglycaemia
- Pregnancy and breastfeeding, no data available
Storage
- Lyophilised
- 2 to 8 °C protected from light. Stable up to 24 months unopened.
- Reconstituted
- 2 to 8 °C. Use within 30 days.
- Shipping
- Stable at ambient temperature in lyophilized form during shipping.
Preguntas frecuentes
Why apply it while fasting?
The AMPK pathway responds to energy deficit; published protocols aim to coincide with that state, although there is no direct comparison with post-meal application.
Research use only
Este compuesto se vende únicamente para investigación de laboratorio y desarrollo analítico. No es un medicamento, no está aprobado por ninguna autoridad sanitaria, y no se vende para diagnosticar, tratar, curar ni prevenir ninguna enfermedad. No es apto para consumo humano ni animal.