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Synthetic fragment 17-23 of thymosin beta-4
TB-500 10 mg
The active fragment of thymosin beta-4, a protein that sequesters actin and takes part in organising the cytoskeleton. It is the region responsible for actin binding, studied as a short, stable form of the complete molecule.
- CAS
- 77591-33-4
- Formula
- C212H350N56O78S
- Molecular weight
- 4963.4 g/mol (timosina beta-4 completa)
- Sequence
- Ac-Ser-Asp-Lys-Pro-Thr-Ser-His-Gln
- Purity
- ≥ 98% verified by HPLC
- Presentation
- Amber glass vial with lyophilized powder, vacuum sealed.
- Includes 3 ml BAC waterIn the same box, at no cost.
$130 USD
How it works
- Sequesters actin monomers and regulates their polymerisation, a necessary condition for cell migration.
- Promotes migration of endothelial cells and progenitors towards the site of injury.
- Downregulates pro-inflammatory mediators in tissue damage models.
- Its low molecular weight lets it distribute to tissues with limited blood supply.
Qué dice la evidencia
- Description of thymosin beta-4's role as an actin-sequestering protein and its function in repair.
- Promotion of endothelial cell migration and vessel formation in cardiac damage models.
Route described in the studies
- Route
- Subcutaneous or intramuscular. Distribution is described as systemic.
- Preparation
- Reconstitute with BAC WATER against the vial wall, without shaking.
- Application site
- Alternate sites between applications during the loading phase.
Documented effects
- Transient fatigue during the first applications
- Local discomfort at the injection site
- Long-term human safety profile not established
When it is not used
- Active neoplasia, given the angiogenic and cell migration activity
- Pregnancy and breastfeeding, no data available
Storage
- Lyophilised
- 2 to 8 °C protected from light. Stable up to 24 months unopened.
- Reconstituted
- 2 to 8 °C. Use within 30 days.
- Shipping
- Stable at ambient temperature in lyophilized form during shipping.
Preguntas frecuentes
Why use a loading phase?
Published protocols aim to reach tissue concentration before spacing applications out; hence the two weekly applications at the start.
Research use only
Este compuesto se vende únicamente para investigación de laboratorio y desarrollo analítico. No es un medicamento, no está aprobado por ninguna autoridad sanitaria, y no se vende para diagnosticar, tratar, curar ni prevenir ninguna enfermedad. No es apto para consumo humano ni animal.