Kisspeptin triggered egg maturation in in-vitro fertilisation

A pioneering study showed this natural peptide can replace the classic hormonal trigger in IVF.

People with mutations that abolish kisspeptin signalling are infertile: the peptide is key to the hormone surge that precedes ovulation. On that basis, this study used kisspeptin-54, the main form circulating in humans, in women undergoing in-vitro fertilisation.

Kisspeptin successfully triggered egg maturation and opened a line of research that continued with trials in women at high risk of ovarian hyperstimulation syndrome.

In three points

Human study in IVF patients
Kisspeptin triggered egg maturation
Led to later trials in high-risk patients

Compounds mentioned

Kisspeptin

Original source: Kisspeptin-54 triggers egg maturation in women undergoing in vitro fertilization
PubMed · Journal of Clinical Investigation

Plain-language summary by SYNTRA LABS based on the original publication and checked against its source. It is not medical advice or a recommendation for use. SYNTRA LABS compounds are for research use only and not for human consumption.